Dr Hans Hinselmann- inventor of the colposcopy machine to detect early precancerous lesion of cervical cancer.Three years later a Greek Physician, Georgios Papanikolaou, a pioneer in cytology in early detection of cancer developed the Pap Smear.
In `1974, A German virologist, Dr, Harald zur Hausen was studying and did research on Carcinoma of Cervix,has found Human Pappilloma Virus DNA in cervical cancer cells, and for this great discovery, he attributed HPV virus as a major causative factor in the development of cervical cancer.
For his discovery, he received the Nobel Prize in Physiology in 2008.
Dr Harald zur Hausenwinner of the Nobel Prize in Physiology for his discovery in Human Pappilloma virus as the causative agent.
In 2007, the first ever vaccine against Cervical cancer, Gardasil, which gives protection not only cancer but prevention of genital wards. However cost is a real factor on why it didn't get much response from the community.

GARDASIL
When it was initially introduced, natually due to its cost (as being the first anti cncer drugs) It boast to be a tetrvalent vaccine, since it covers serotype 18 and serotype 16, then the other 2 that contribute to genital warts.

GARDASIL
When it was initially introduced, natually due to its cost (as being the first anti cncer drugs) It boast to be a tetrvalent vaccine, since it covers serotype 18 and serotype 16, then the other 2 that contribute to genital warts.
GSK, a giant pharmaceutikal company that produces Cervarix came into the market in the mid 2008.
Being bivalent vaccine that provides 100% protection against HPV16 and HPV 18, with some cross protection with serotype 31 and 45.
However, the latest data indicated tht Cervarix give 100% protection against HPV 16,HPV18,HPV31, and HPV 45. So, my friends! Cervarix has become a tetrvalent vaccine now.

Being bivalent vaccine that provides 100% protection against HPV16 and HPV 18, with some cross protection with serotype 31 and 45.
However, the latest data indicated tht Cervarix give 100% protection against HPV 16,HPV18,HPV31, and HPV 45. So, my friends! Cervarix has become a tetrvalent vaccine now.
Based on the head to head studies, Cervarix has been proven to be far more superior than Gardasil.
So, what are you waiting for?
Next topic, on pap smear. You'll be surprised!

Dear Wise Doctor.... I'm curious...
ReplyDeleteDo you really need to take all 3 doses ?
If you do, how far apart are doses supposed to be taken ?
dear Malikboy,
ReplyDeleteCall me chee hung from now on. No need the formality.
Yes, You would need to take 3 doses, and though this timing for this particular vaccine is particularly flexible(thanks to the adjuvant ASO4), somehow the recommended timing is same as hepatitis B, that's 0 month(the first dose), 1month(second dose)then 6month(5 months after the 2nd dose)
Thanks for the info !
ReplyDelete